THE PROBLEMS OF BIOCOMPATIBILITY OF TITANIUM AND HAFNIUM NITRIDE-BASED COATING METALLIC IMPLANTS FOR OSTEOSYNTHESIS

E.V. Kruglova (1), V.A. Patrikeev (1), V.A. Vedin (1), I.M. Zurina (2), I.N. Saburina (2),
T.I. Khomyakova (3), T.Kh. Borzenkova (4), Yu.N. Khomyakov (1)
1-ZAO «Medmash», Khlebozavodsky proezd, 7, building 9, Moscow, 115230, Russian Federation;
2-Institute of General Pathology and Pathophysiology, Baltiyskaya str., 8, Moscow, 125315, Russian Federation;
3-Research Institute of Human Morphology, Tsyurupa str., 3, Moscow, 117418, Russian Federation;
4-Industrial hospital No164, Solnechnaya str., 2, Obolensk, 142279, Russian Federation
E-mail: khomyakovyuri@yandex.ru

Introduction. At the present time the attention to the development of implant coating is growing in the fields of surgery, odontology, traumatology and orthopedy because of its possibility to improve the stability of metal implants on the one hand and to provide a sufficient biocompatibility with the microenvironment on the other hand. The infecting of implant surfaces leads to the development of severe both local lesions and system disorders. One of the approaches to the solving the problem is related with the coating of implant surfaces with a bacteriostatic cover. The aim of the study. The aim of the present work was to investigate a biocompatibility and bacteriostatic action of the metal specimens with arc spraying coating on the base of different equity proportion of titanium and hafnium nitride in comparison with an identical non-coating metal and a neutral substrate. Methods. The currently accepted method of the estimation of biocompatibility was used. We studied the human fibroblasts adhesion to the coated and non-coated specimens as well as the action to the morphological properties of a cell culture in vitro. The evaluation of a bacteriostatic action was made with the use of test-cultures Escherichia coli ATCC 25922, Staphylococcus aureus АТСС 6538-Р and Pseudomonas aeruginosa GISK453. Results. All coated specimens were estimated to have no influence on morphology and sizes of the human fibroblasts in a culture; a high level of biocompatibility was proved. A statistically significant bacteriostatic action was recognizing in all bacterial test-cultures with the inverse relation of the hafnium content. Conclusion. The titanium and hafnium nitride-based coating was shown to provide a biocompatibility with the microenvironment and bacteriostatic action in vitro.
Keywords: 
implants, bacteriostatic effect, biocompatibility, titanium and hafnium nitrides