EXOSOMES FROM VARIOUS BIOLOGICAL FLUIDS: PATTERN AND FUNCTION

N.V. Yunusova (1, 2), S.N. Tamkovich (3), I.V. Kondakova (1)
1-Tomsk Cancer Research Institute, Kooperativny str., 5, Tomsk, 634009, Russian Federation;
2-Siberian State Medical, Moskovskij tract, 2, Tomsk, 634050, Russian Federation;
3-Institute of chemical biology and fundamental medicine Siberian branch of Russian academy of science,
Lavrentiev Ave., 8, Novosibirsk, 630090, Russian Federation
4Novosibirsk State University, Pirogova, 2, Novosibirsk, 630090, Russian Federation
E-mail: BochkarevaNV@oncology.tomsk.ru

Exosomes are microscopic extracellular vesicles with diametr 30–100 nm, which are secreted by different types of cells and may be detected in normal (blood serum, saliva, urine, breast milk) and pathological (ascite) biological fluids. It was shown that exosomes contain a proteins and nucleic acids and participate in cell-to-cell signaling. In this review data concerning exosomal protein, lipidic and nucleic acid contents are systemized and exosomalfunctions in biological fluids are analyzed. It was shown summarized data on immunomodulatory influence of different origin exosomes. The main problemsof exosome investigation of exosomes in human biological fluids such as different approaches for isolation and identification of exosomes, heterogeneityand composite content of exosomes from biological fluids against exosomes from cultivated cell lines are discussed. It was described main functions of exosomes in cancer pathogenesis.
Keywords: 
extracellularvesicles, exosomes, biologicalfluids, cancerpathogenesis