ROLE OF MOLECULES OF ANGIOGENESIS IN INTERSTITIAL LUNG DISEASES

E.N. Popova (1), A.B. Ponomarev (1), E.M. Paltseva (2), M.V. Lebedeva (1), E.A. Kazina (1), I.A. Popova (1)
1 -I.M. Sechenov First Moscow State Medical University, Trubetskaya Str., 8, Moscow, 119991, Russian Federation;
2 -B.V. Petrovsky Russian Surgery Research Center, Abrikosovskiy by-street, 2, Moscow, 119991, Russian Federation

Introduction. In interstitial lung diseases (ILD), characterized by inflammatory and fibrous processes, the intensification of angiogenesis also occurs. The aim of our research. Was the study of characteristics of expression angiogenic molecules (VEGF, ET1) in some ILD variants at different stages of their progression. Methods. standard clinical examination of patients with different ILD types, determination of VEGF and ET1 blood levels by the method of immunosorbent assay; morphological survey of lung biopsies and identification of VEGF expression by the method of immunohistochemistry. Results. VEGF and ET1 blood concentration in all patients with ILD was significantly higher in comparison with control and correlated with the degree of fibrosis according to computer tomography data. The intensity of angiogenesis was detected by the assessment of VEGF expression correlated with VEGF and ET1 blood concentrations and with the grade of fibrosis. The association of the wall thickness of remodeled vessels and VEGF and ET1 blood levels is revealed. Reliable difference between groups of ILD patients with signs of disease activity and without them is shown in dependence of VEGF and ET1 levels. Conclusion. These data demonstrate that VEGF and ET1 play an important role in the ILD progression as markers of endothelial dysfunction and angiogenesis.
Keywords: 
interstitial lung diseases, fibrosis, angiogenesis, vascular endothelial growth factor, endothelin-1, sarcoidosis