IL1β GENE POLYMORPHISM IN CHRONIC VIRAL HEPATITIS B AND C IN CHILDREN

Introduction. One of the important tasks of hepatology is the prognosis of viral hepatitides. The prognosis is based on the analysis of genetic determination of the functioning of antiviral immunity, particularly, of the cytokine system. The aim of the study was to reveal the characteristics of the influence of IL1β gene polymorphism on immune reactions in chronic viral hepatitis B (HBV) and C (HCV) in children. Methods. Polymorphism of gene IL1β-31T/C and -511С/Т was revealed in 48 children aged from 6 to 17 years by allele-specific polymerase chain reaction, the detection of amplification products was performed with the use of horizontal electrophorsis. Results. Polymorphism-31 Т/С in gene IL1β was associated with the increased risk of chronic viral hepatitis in HВV and HСV infection (p=0,048). СС genotype of gene IL1β-511 and genotypes ТТ and СС -31 were associated with the decline in adaptive immunity efficiency in the form of the reduced number of СD8+-lymphocytes (p=0,017; p=0,035; p=0,038), and genotype ТТ-511 – with the decreased humoral activity of blood serum according to IgM level (p=0,027) that can contribute to the prolonged persistent course of chronic viral hepatitis. Genotypes ТТ in -511 position and СС in -31 position were characterized by higher IL1β level in the blood serum. Conclusion. In children with chronic viral hepatitis B and C there is the association of polymorphism gene IL1β-31 Т/С and -511С/Т with peculiarities of the course of the disease