CONTENT OF EPIDERMAL GROWTH FACTOR RECEPTORS AND ITS LIGANDS IN OVARIAN TUMORS

Results of radioligand determination of epidermal growth factor receptor (EGFR) and radioreceptor assessment of EGF-like peptides’ (EGFLP) levels in the tumors of 44 ovarian cancer and 10 benign ovarian tumor patients are presented. Frequency of revelation and content of EGFR in ovarian cancer were significantly higher than in benign tumors, whereas no differences between benign and malignant ovarian lesions were revealed for EGFLP levels. In the majority (60%) of benign tumors EGFR– EGFLP– receptor phenotype was demonstrated, while such marker combination was found in only 35% of ovarian cancer samples.