RANK/RANKL/OPG SYSTEM IN BONE METASTASES AND PRIMARY BONE TUMORS

 Download full text (PDF)

N.E. Kushlinskii, Yu.A. Timofeev, E.S. Gershtein
N.N. Blokhin Russian Cancer Research Center, Moscow

RANK/RANKL/OPG system – is a key element in bone homeostasis. In this review we depict the basic principles of functioning of this system and known genetical anomalies affecting its components. Also we describe a number of pathological states associated with disorders in RANK/RANKL/OPG system and consider the role of this system in development of bone metastases and in primary bone tumors.
Keywords: 
RANK, RANKL, OPG, tumors, metastases, bones