THE RISK ASSESSMENT OF DEVELOPMENT OF CHOROIDAL NEOVASCULARIZATIONIN AGE-RELATED MACULAR DEGENERATION

The Hebrew University-Hadassah Schools of Medicine and Dental Medicine, Jerusalem, Israel

Aim. To study a method of risk assessment neovascular age-related macular degeneration (AMD) with the genetic and clinical risk factors. Methods. The study included 255 patients with neovascular AMD (NVAMD) and 119 subjects in control group. Diagnosis and stages of AMD were set as recommended by AREDS. The mean age of patients in the control group (70,8±8,2 years) was lower than in the NVAMD group (78,1±7,6 years). All studied cases were genotyped for rs11200638 in the gene HTRA1, rs10490924 in the gene LOC387715/ARMS2, rs1061170 in the gene CFH. Determination of polymorphisms was performed by sequencing PCR products containing data SNPs. Results. In the NVAMD group polymorphisms rs11200638 and rs10490924 have almost complete adhesion, D'=0,96–1,00. The differences in the distribution of alleles and genotypes of these SNPs in AMD patients and control groups were statistically significant. The relationship of smoking and NVAMD development(OR=3,95% CI 1,7–5,3, p
Keywords: 
choroidal neovacularization, neovascular AMD, singlenucleotide polymorphism