ASSOCIATION OF IL-4Rα POLYMORPHISM WITH THE DEVELOPMENTOF IMMEDIATE HYPERSENSITIVITY REACTIONS TO BETA-LACTAM ANTIBIOTICS

The development of allergic reactions to beta-lactam antibiotics is largely determined by genetic factors. In this work, to study the association of gene polymorphisms IL-4Rα (rs1801275) with the development of immediate hypersensitivity reactions (RGNT) to betalactam antibiotics in the russian population of patients genotypic frequencies of rs1801275 polymorphism of this gene were investigated. The study showed a statistically significant difference in the gene polymorphism IL-4Rα (rs1801275) between the control group and the group of patients with RGNT to beta-lactam antibiotics. The association between the development of IRR to beta-lactam antibiotics and genotype AARGNT in russian patients was demonstrated (OR=3,50; CI95% [1,82–6,72]; р=0,0001).