PROTEOMIC PATTERNS OF BIOLOGICAL FLUIDS IN PATIENTS WITH HEAD AND NECK SQUAMOUS CELL CARCINOMA

Head and neck squamous cell carcinoma is one of the aggressive forms of cancer, which often presents at advanced stages, being associated with poor prognosis and low survival rates. Therefore, the delivery new biomarkers for early cancer detection and prediction of tumor response to target therapy seems to be necessary. The proteomic technologies allow to conduct the large-scale studies of changes in protein profile of tissues and biological fluids, thus discovering new approaches to the laboratory diagnosis. Identified proteins can be used as markers for early cancer detection and prediction of the chemotherapy response. Solution of the problems related to the interpretation of data, different methodological approaches and incompleteness of many studies, allow to determine with sufficient certainty what proteins can be suggested to use in clinical settings.