MOLECULAR BASIS OF DEVELOPMENT AND PROGRESSION OF HEART FAILURE IN MIDDLE AND OLD AGE

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K.I. Prashchayeu (1,2), A.N. Ilnitski (1), V.I. Bessarabov (1), T.V. Pavlova (2), T.V. Kvetnaya (3), O.A. Bolhovitina (2), N.M. Pozdnyakova (1,2)
1 -Non-commercial Organization «Researching Medical Center «GERONTOLOGIY», Moscow, Russian Federation,
2 -National Research University Belgorod State University, Belgorod, Russian Federation,
3 -Saint Petersburg Institute of Bioregulation and Gerontology of the North-West Branch of the Russian Academy of Medical Sciences, St. Petersburg, Russian Federation

This article discusses the current level of research on the molecular mechanisms of development and progression of chronic heart failure in elderly and senile age. Described contribute to the pathogenesis of diseases of various signaling molecules and subsystems from the point of view neuro-immuno-endocrinology. The significance of cytokines and endothelial dysfunction in the pathogenesis of the disease is proved. Put forward a new hypothesis about the role of TNF-α in the development of chronic heart failure.
Keywords: 
Chronic heart failure, neuro-immuno-endocrinology, advanced age, cytokines, tumor necrosis factor-α