CLINICAL VALUE OF BONE REMODELING MARKERSIN BREAST CANCER PATIENTSWITH SKELETAL METASTASES
The dependence of biochemical markers of bone resorption (C-terminal telopeptide of type I collagen – b-CTx, deoxypyridinoline –
DPID, tartrate-resistant acid phosphatase (TRAP) 5b) and osteosynthesis (bone alkaline phosphatase – BALP) on clinical manifestations
of bone metastases in 239 patients with breast cancer (BC) has been established with the use of ELISA method. In patients with bone
metastases (n=72) DPID excretion in the urine, and the seru concentration of CTx and activity of TRAP and BALP level were found to
be significantly higher if compared with BC patients without bone lesions (n=167), and healthy females (n=47). However, their significant
increase (p
Keywords:
deoxypyridinoline, C-terminal telopeptide of type I collagen, tartrate resistant acid phosphatase 5b, bone alkaline
phosphatase, prognosis, bone metastases, breast cancer