EXPRESSION OF HUMAN PROTEINS UNDER THE EXTERNAL AND INTERNAL IRRADIATION

V.L. Rybkina, T.V. Azizova
South Ural Biophysics Institute, Ozerskoe shosse, 19, Ozersk, 456780, Russian Federation
E-mail: clinic@subi.su

The data concerning the changes of expression and posttranslational modification of the human protein under the influence of the external and internal irradiation in vivo and in vitro are presented in this review. The investigation of protein expression and posttranslational modification of proteins is a key for understanding of mechanisms of the development of immediate and remote effects of radiation exposure. The importance of the investigations of the protein expression under irradiation is determined also by the possibility of the using the obtained data for biological indication and biological dosimetry. Besides, proteins may be biological markers of radiosensitivity and radioresistance, that is of great importance in oncology in treatment of malignant tumors and in the formation of risk group for contingents exposed to irradiation with a purpose of regular medical check-up and late effects prophylactics. The response of cells to ionizing irradiation is manifested by the activation of the great number of signaling pathways, leading to the alteration of the expression of the great quantity of proteins. First of all these proteins are signaling about the presence of DNA breaks, proteins taking part in its reparation, cell cycle control, apoptosis, proto-oncogenes, pro-inflammatory proteins, folding proteins, enzymes.
Keywords: 
expression, external irradiation, internal irradiation, biological indication, biological dosimetry