THE INFLUENCE OF NANOPARTICLES ON BIOLOGICAL INTEGRITY OF HUMAN PLATELETS

M.S. Makarov
N.V. Sklifosovsky Scientific Research Institute of Emergency Medicine, B. Sukcharevskaya sq., 3, Moscow, 129090, Russian Federation
Е-mail: mcsimmc@yandex.ru

The review presents data concerning the interaction of basic types of nanoparticles with human platelets in vitro and in vivo and biological results of this influence. The initial structure of nanoparticles and their biologically active cargo can both stimulate injury of platelets. Many types of nanoparticles, such as silicates (SiO2), nanogold, quantum dots (CdSe и CdTe), carbon nanotubes, big positive-charged poly-amid-amino-dendrimers induce different ways of the spontaneous activation of platelets in vitro и in vivo. Nano-sized platelet-mimetic liposomes could be used as the non-canonic hemostasis co-factor. The presence of stable positive-charged core enhances aggregative abilities of nanoparticles, moreover, nanoparticle-induced activation of platelet is mainly followed by the membrane influx. The organic polymer cover obviously enhances biocompatibility of nanoparticles.
Keywords: 
nanoparticles, platelets, activation, degranulation