CLINICAL SIGNIFICANCE OF EPIDERMAL GROWTH FACTORS AND SEX STEROIDS IN ENDOMETRIAL TUMORS

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R.R. Azhigova (1), O.M. Kuznetsova (1), D.E. Galdava (2), E.K. Dvorova (2), K.P. Laktionov (2), T.T. Berezov (1)
1 -Peoples’ Friendship University of Russia, Moscow
2 -N.N. Blokhin Russian Cancer Research Center, Moscow

The study data of the epidermal growth factor receptors(EGFR), estrogen and progesterone receptors(ER, PR) in the endometrial tumors in 125 patients are presented. EGFR have been detected in 40% of tumors. The EGFR–RP+ER+ tumors were detected most frequently (48,8%) and EGFR+ER+PR+ (30,4%) were identified less often. The frequency of detection of EGFR in the tumor being more informative than its level in patients with endometrial cancer decreased in cases of unfavorable clinical and morphological characteristics of the disease. The relationship between the expression of EGFR, ER and PR with a prognosis of endometrial cancer is discussed
Keywords: 
endometrial cancer, EGFR, ER, PR, prognosis