NEUROENDOCRINE TUMORS OF PANCREAS: MOLECULAR MECHANISMS OF ONCOGENESIS AND TARGETED THERAPY

In the article a review of recent data on the molecular nature of neuroendocrine tumors of the pancreas (pancreatic NETs) is presented. The genetic basis of inherited syndromes associated with the development of pancreatic NETs: multiple endocrine neoplasia type 1, von Hippel-Lindau disease, neurofibromatosis type 1, tuberous sclerosis is elucidated. The actual and promising methods of target therapy of pancreatic NETs are considered. The results of randomized placebo-controlled studies of the III phase that evaluate the efficacy of everolimus and sunitinib in the treatment of disseminated non-resectable forms of pancreatic NETs have been analyzed.