THE GROWTH FACTORS AND ADHESION MOLECULES OF VESSEL ENDOTHELIUMAS TARGETS FOR CREATION OF PEPTIDE DRUGS AGAINST ATHEROSCLEROSIS

V.V. Malinin (1), A.O. Durnova (2), V.O. Polyakova (2)
1 -Medical-Biological Research-Industrial Complex «Cytomed»; 2 -The Research Institute of Obstetrics and Gynecology named after D.O. Ott of the North-West Branch of the Russian Academy of Medical Sciences, St. Petersburg, Russian Federation

The expression of adhesion molecules (ICAM-1, E-selectin) and growth factors (PDGF, bFGF, TGF-β) was investigated in cultures of human endotheliual cells in health and atherosclerosis. Expression of ICAM-1, E-selectin, bFGF, TGF-β was shown to decline in atherosclerotic endothelium, but the synthesis of PDGF didn’t change. The investigation of biological effects of peptide Lys-Glu-Trp has shown the possibility of its using as a potential drug for molecular target therapy of atherosclerosis.
Keywords: 
adhesion molecules, growth factors, endothelium, atherosclerosis, tripeptide