POLYMORPHYSMS OF XENOBIOTICS BIOTRANSFORMATION AND CELL PROLIFERATION CONTROL GENESAND THEIR ASSOCIATION WITH RISK OF CANCER OF RESPIRATORY TRACT IN POPULATION OF MOSCOW REGION

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M.V. Atkarskaya, T.M. Zavarykina, G.P. Zhizhina, E.B. Burlakova
Emanuel Institute of Biochemical Physics RAS, Moscow

The associations of polymorphic markers of the xenobiotics – metabolizing genes (GSTТI, GSTМI, GSTPI), cell cycle regulation genes (ТР53,CDKNI) and of the gene XRCCI repairing damaged DNA bases in 54 healthy subjects and 50 patients with upper respiratory tract cancer (URTC) have been studied in the paper. Genotyping was performed by PCR-RFLP method. The high frequency of occurrence of predisposing alleles and genotypes of polymorphic markers for these genes in URT cancer patients has been shown. Our results revealed an increased risk of URTC development associated with predisposing genotypes of polymorphic markers: of the TP53 gene (Arg72Pro and Gln157Lys) and the CDKNI (Ser31Arg) in patients.. It is also found that the presence of the genotype GSTPIIle/ Val, XRCCI-Gln /Gln and TP53-Pro/Pro is associated with the risk of URTC development in smokers (OR=3,9; 3,45 and 32,4 respectively). The results indicate the important role of cell cycle regulation genes in the development of URT cancer in population of Moscow region.
Keywords: 
cancer, risk, respiratory tract, glutathione-S-transferase, biotransformation of xenobiotics, cell cycle, polymorphism, null alleles, smoking

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